Journal
GASTROENTEROLOGIA Y HEPATOLOGIA
Volume 41, Issue 2, Pages 128-142Publisher
ELSEVIER ESPANA SLU
DOI: 10.1016/j.gastrohep.2017.07.006
Keywords
Body mass index; Visceral obesity; Obeticolic acid; Peroxisome prolifqrator-activated receptor; Glucagon-like peptide-1 receptor agonists
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Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able to improve steatosis, ballooning and fibrosis. Life-style interventions based on Mediterranean diet and increasing physical activity are the first line therapy. In patients with unsuccessful life-style intervention several drugs are under development: agonist PPAR, agonist GLP-1R and agonist FXR together with drugs focussing on inflammation, ballooning, apoptosis and fibrosis. Bariatric surgery or advanced endoscopy are reserved for morbid obese without response to life-style intervention and weighting loss drugs. (C) 2017 Elsevier Espana, S.L.U. All rights reserved.
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