Journal
FUTURE VIROLOGY
Volume 13, Issue 3, Pages 211-223Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fvl-2017-0106
Keywords
cis-acting elements; host mRNA decay; virus
Categories
Funding
- NIH [AI057484, AI072068, T32 AI83196]
- Lymphoma Research Foundation
- Department of Medicine at the University of Minnesota
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI083196, R01AI072068, R56AI057484] Funding Source: NIH RePORTER
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Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to evade host antiviral responses to allow viral survival and replication. We discuss different cellular RNA decay pathways, including the deadenylation-dependent mRNA decay pathway, and various strategies that viruses exploit to manipulate these pathways in order to create a virus-friendly cellular environment.
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