Related references
Note: Only part of the references are listed.Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases
Matias Gonzalez-Quiroz et al.
SEMINARS IN CANCER BIOLOGY (2018)
Activation of the c-Jun N-Terminal Kinase Pathway Aggravates Proteotoxicity of Hepatic Mutant Z Alpha1-Antitrypsin
Nunzia Pastore et al.
HEPATOLOGY (2017)
Down-Regulation of Hepatocyte Nuclear Factor-4α and Defective Zonation in Livers Expressing Mutant Z α1-Antitrypsin
Pasquale Piccolo et al.
HEPATOLOGY (2017)
Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation
Nazli Khodayari et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy
Lijie Feng et al.
AUTOPHAGY (2017)
Opportunistic intruders: how viruses orchestrate ER functions to infect cells
Madhu Sudhan Ravindran et al.
NATURE REVIEWS MICROBIOLOGY (2016)
Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis
Joseph C. Genereux et al.
EMBO JOURNAL (2015)
Alpha-1-antitrypsin deficiency: from genoma to liver disease. PiZ mouse as model for the development of liver pathology in human
Isabella Giovannoni et al.
LIVER INTERNATIONAL (2015)
A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover
Olivia S. Long et al.
HUMAN MOLECULAR GENETICS (2014)
Plasmodial Hsp40 and Hsp70 chaperones: current and future perspectives
E. -R. Pesce et al.
PARASITOLOGY (2014)
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
Luke R. G. Pike et al.
BIOCHEMICAL JOURNAL (2013)
p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose
Anne-Laure Huber et al.
MOLECULAR CELL (2013)
PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS
Kasper M. Rouschop et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response
Anika Nagelkerke et al.
BREAST CANCER RESEARCH (2013)
The Endosomal Protein-Sorting Receptor Sortilin Has a Role in Trafficking α-1 Antitrypsin
Cristy L. Gelling et al.
GENETICS (2012)
Characteristics of hepatocellular carcinoma in a murine model of alpha-1-antitrypsin deficiency
Nancy Y. Marcus et al.
HEPATOLOGY RESEARCH (2010)
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia
Tomasz Rzymski et al.
CELL CYCLE (2009)
Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in alpha-1-antitrypsin deficiency
D. H. Perlmutter
CELL DEATH AND DIFFERENTIATION (2009)
Epithelial-mesenchymal transition in hepatocellular carcinoma
Franziska van Zijl et al.
FUTURE ONCOLOGY (2009)
PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice
Sounak Gupta et al.
PLOS ONE (2009)
ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
Denis M. Schewe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Small molecules block the polymerization of Z α1-antitrypsin and increase the clearance of intracellular aggregates
Meera Mallyat et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Regulator of G signaling 16 is a marker for the distinct encloplasmic reticulum stress state associated with aggregated mutant α1-antitrypsin Z in the classical form of α1-antitrypsin deficiency
Tuncla Hidvegi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
Jaime D. Blais et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Pathogenesis of chronic liver injury and hepatocellular carcinoma in alpha-1-antitrypsin deficiency
David H. Perlmutter
PEDIATRIC RESEARCH (2006)
Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: One for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ
KB Kruse et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Accumulation of mutant α1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFκB, and BAP31 but not the unfolded protein response
T Hidvegi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Grp78, Grp94, and Grp170 interact with α1-antitrypsin mutants that are retained in the endoplasmic reticulum
BZ Schmidt et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates
Y Shen et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α
C Koumenis et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Worldwide racial and ethnic distribution of α1-antitrypsin deficiency -: Summary of an analysis of published genetic epidemiologic surveys
FJ de Serres
CHEST (2002)
A naturally occurring nonpolymerogenic mutant of α1-antitrypsin characterized by prolonged retention in the endoplasmic reticulum
L Lin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)