Journal
FUTURE MICROBIOLOGY
Volume 13, Issue 6, Pages 671-687Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2017-0115
Keywords
antibacterial; antibiotic resistance; antivirulence therapy; gastric cancer; Helicobacter pylori; peptic ulcer
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Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a major risk factor for the development of peptic ulcer disease and gastric cancer. Current standard eradication therapies use an acid-suppressing drug and two antibiotics, now frequently supplemented with bismuth. Declining eradication efficiencies, off-target effects of lengthy broad-spectrum antibiotic treatments and the desire of a more systematic eradication in asymptomatic H. pylori carriers to suppress gastric cancer incidence spur a search for an effective vaccine and alternative therapeutic options. Here, we review the current progress in the field, with an emphasis on narrow-spectrum or nonantibiotic therapeutics. [GRAPHICS] .
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