Journal
FUTURE MEDICINAL CHEMISTRY
Volume 10, Issue 10, Pages 1229-1239Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2017-0235
Keywords
antidiabetic; dipeptidyl peptidase IV; DPP-IV inhibitors; Type 2 diabetes
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Funding
- Recruitment Program of Global Experts
- Director Foundation of XTIPC, CAS [2015RC011]
- Natural Science Foundation of Xinjiang, China [2016D01A073]
- Central Asian Drug Discovery and Development Center of Chinese Academy of Sciences
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Diabetes mellitus is an increasing public health problem in the world. Type 2 diabetes is the most common type of diabetes whose complications contribute to its high death rate. It seriously impacts healthcare systems and patients' quality of life. Therefore, effective measures and new treatment strategies are needed to solve this increasingly serious global problem. In recent years, inhibition of dipeptidyl peptidase IV (DPP-IV) has emerged as a new treatment option for Type 2 diabetes. This article reviews various plant DPP-IV inhibitors that showed inhibition toward enzyme as a major target for the management of Type 2 diabetes. These studies can contribute to the future development of DPP-IV inhibitors as drugs.
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