Journal
FUTURE MEDICINAL CHEMISTRY
Volume 10, Issue 6, Pages 663-677Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2017-0249
Keywords
bioinorganic chemistry; drug delivery; metal complexes
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This review focuses on metal complexes of cyclodextrin (CyD) derivatives designed for application as therapeutics or diagnostics. We discuss examples of metalloprotein models (hemoglobin, superoxide dismutase and catalase) based on cyclodextrins. The hydrophobic microenvironment of CyDs stabilizes the Fe(II) porphyrin system that can reversibly bind O-2 or CO in water. Superoxide dismutase/catalase mimetics exploit functionalization with CyDs, which increase their solubility and biological activity. Furthermore, CyDs have been used as scaffolds to obtain multicenter metal complexes: paramagnetic systems act as high-performance contrast agents for magnetic resonance imaging applications. Finally, we review CyD ligands, whose use appears promising in metal chelation therapy, as CyD moiety confers additional properties to the ligands.
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