Journal
FUTURE MEDICINAL CHEMISTRY
Volume 10, Issue 11, Pages 1361-1368Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2017-0294
Keywords
drug repurposing; MAMUT; natural product panaceas; network pharmacology; polypharmacology
Categories
Funding
- Ministry of Education (MOE) from Ministry of Education Singapore [R-148-000-241-114]
- MOE
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The once-popular approach of using natural products as a prime source for medicinal chemistry and drug discovery has waned considerably in the past two decades due to the advent of high-throughput screening of small moleculemega libraries. However, the growing appreciation of network pharmacology as the next drug-discovery paradigm suggests that natural products and their unique polypharmacology offer significant advantages for finding novel therapeutics particularly for the treatment of complex and multifactorial diseases. Drug discovery process is awaiting the revitalization of interest in natural products and their derivatives. The current challenge is how to decipher this natural chemical diversity.
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