Journal
FUTURE MEDICINAL CHEMISTRY
Volume 10, Issue 2, Pages 231-256Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2017-0164
Keywords
pain; sigma-1 receptor; sigma-1 receptor antagonist
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Sigma-1 (sigma(1)) receptor has been identified as a chaperone protein that interacts with other proteins, such as N-methyl-D-aspartate (NMDA) and opioid receptors, modulating their activity. sigma(1) receptor antagonists have been developed to obtain useful compounds for the treatment of psychoses, pain, drug abuse and cancer. Some interesting compounds such as E-5842 (5) and MS-377 (24), haloperidol and piperazine derivatives, respectively, were endowed with high affinity for s1 receptors (K-i sigma(1) = 4 and 73 nM; K-i sigma(2) = 220 and 6900, respectively). They were developed for the treatment of psychotic disorders and 5 also underwent Phase II clinical trials suggesting interesting potential therapeutic applications. Here, s1 receptor antagonists have been grouped based on chemical structure and reviewed according to structure-activity relationship and potential therapeutic role.
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