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Bacterial versatility requires DEAD-box RNA helicases

Journal

FEMS MICROBIOLOGY REVIEWS
Volume 39, Issue 3, Pages 392-412

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/femsre/fuv011

Keywords

RNA helicase; ribosome biogenesis; translation initiation; RNA turnover; bacteria; gene expression

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Funding

  1. Swiss National Science Foundation
  2. canton of Geneva
  3. Boninchi foundation
  4. E & L Schmidheiny foundation
  5. Novartis Consumer Health Foundation
  6. Swiss Life
  7. Novartis Jubilaums foundation

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RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. In bacteria, they are known to be involved in ribosome biogenesis, RNA turnover and translation initiation. They thereby play an important role in the adaptation of bacteria to changing environments and to respond to stress conditions.

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