Journal
FRONTIERS IN HUMAN NEUROSCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnhum.2018.00040
Keywords
monitoring general anesthesia; directed transfer function (DTF); electroencephalography (EEG); consciousness; general anesthesia
Categories
Funding
- European Union [7202070]
- Norwegian Research Council [NRC: 262950/F20, 214079/F20]
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Objective: The objective of this study was to test whether properties of 1-s segments of spontaneous scalp EEG activity can be used to automatically distinguish the awake state from the anesthetized state in patients undergoing general propofol anesthesia. Methods: Twenty five channel EEG was recorded from 10 patients undergoing general intravenous propofol anesthesia with remifentanil during anterior cervical discectomy and fusion. From this, we extracted properties of the EEG by applying the Directed Transfer Function (DTF) directly to every 1-s segment of the raw EEG signal. The extracted properties were used to develop a data-driven classification algorithm to categorize patients as anesthetized or awake for every 1-s segment of raw EEG. Results: The properties of the EEG signal were significantly different in the awake and anesthetized states for at least 8 of the 25 channels (p < 0.05, Bonferroni corrected Wilcoxon rank-sum tests). Using these differences, our algorithms achieved classification accuracies of 95.9%. Conclusion: Properties of the DTF calculated from 1-s segments of raw EEG can be used to reliably classify whether the patients undergoing general anesthesia with propofol and remifentanil were awake or anesthetized. Significance: This method may be useful for developing automatic real-time monitors of anesthesia.
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