Journal
NANOTECHNOLOGIES IN RUSSIA
Volume 10, Issue 5-6, Pages 458-467Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S1995078015030179
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An assessment of the reproductive toxicity of multiwalled carbon nanotubes (MWCNTs) for male laboratory mice according to a set of morphophysiological, biochemical, and histological criteria is reported. Oral administration of MWCNTs at doses of 0.3, 3, and 30 mg/kg evoked a dose-dependent decrease in the level of free testosterone in blood plasma, as well as a 15-40% decrease in male fertilization capacity. Mathematical modeling allowed for the assumption that a decrease in the parameter named above can induce changes in the population dynamics of mouselike rodents, namely, a reduction in the peak numbers of animals and an increase of the oscillation period by similar to 30%. The results can be used for developing environmental standards of MWCNT intake by mammals, as well for the development of new products for controlling rodent populations.
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