Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 23, Issue -, Pages 146-161Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4585
Keywords
Chronic kidney disease; Dyslipidemia; End Stage Renal Disease; Lipid Metabolism; Cardiovascular Disease; Lipoprotein; Hemodialysis; Review
Categories
Funding
- Office of Research and Development of the Department of Veterans Affairs [1 IK CX 001043-01A2]
- Veterans Affairs [IK2CX001043] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Chronic kidney disease (CKD) is a progressive condition marked by protracted kidney damage which overtime can lead to end stage renal disease (ESRD). CKD can be categorized into different stages based on the extent of renal damage and degree of renal dysfunction with ESRD requiring renal replacement therapy considered the final stage. It is important to note that CKD in all of its forms is associated with accelerated atherosclerosis, cardiovascular (CV) disease and poor CV outcomes. While a number of factors contribute to the high risk of CV mortality in this patient population, dyslipidemia is considered to be a key player in the pathogenesis of CV disease in CKD. Molecular mechanisms responsible for CKD-associated lipid disorders are unique and greatly influenced by the stage of renal disease, presence and degree of proteinuria and in patients with ESRD, modality of renal replacement therapy. This article provides a detailed overview of the molecular mechanisms which cause dyslipidemia and the nature of lipid disorders associated with CKD and ESRD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available