Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 23, Issue -, Pages 967-996Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4629
Keywords
Leishmaniasis; Treatment; Drug Repurposing; Review
Categories
Funding
- Fundacao de Apoio a Pesquisa do Estado do Rio de Janeiro [E-26/010.0.01828/2016]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
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The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is inefficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases. The discovery of new clinical applications for approved drugs is strategic for lowering the cost of drug discovery since human toxicity assays are already conducted. Here, we review a broad analysis of the different aspects of this approach for anti-leishmanial treatment.
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