Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 23, Issue -, Pages 1564-1586Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4661
Keywords
CTC1; STN1; TEN1; CST; AAF; DNA replication; Telomere; Review
Categories
Funding
- National Institutes of Health grant [R00 GM104409]
- University of South Carolina
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The human CTC1-STN1-TEN1 (CST) complex is a single-stranded DNA binding protein that shares homology with RPA and interacts with DNA polymerase alpha/primase. CST complexes are conserved from yeasts to humans and function in telomere maintenance. A common role of CST across species is in the regulation of telomere extension by telomerase and C-strand fill-in synthesis. However, recent studies also indicate that CST promotes telomere duplex replication as well the rescue of stalled DNA replication at non-telomeric sites. Furthermore, CST dysfunction and mutation is associated with several genetic diseases and cancers. In this review, we will summarize what is known about CST with a particular focus on the emerging roles of CST in DNA replication and human disease.
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