Journal
FREE RADICAL RESEARCH
Volume 52, Issue 11-12, Pages 1256-1265Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715762.2018.1453137
Keywords
Cardiomyocyte; contractility; free radical; metabolism; mitochondria
Categories
Funding
- National Natural Science Foundation of China [NSFC91649106, 31570777, 31770917, NSFC31771371]
- National Basic Research Program (973 program) [2015CB553602]
- Fundamental Research Funds for the Central Universities [08143008, 08143001]
- Xia(sic)(TM) an Jiaotong University
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The multipurpose organelle mitochondria play an essential role(s) in controlling cardiac muscle contraction. Mitochondria, not only function as the powerhouses and the energy source of myocytes but also modulate intracellular Ca2+ homeostasis, the production of intermediary metabolites/reactive oxygen species (ROS), and other cellular processes. Those molecular events can substantially influence myocardial contraction. Mitochondrial dysfunction is usually associated with cardiac remodelling, and is the causal factor of heart contraction defects in many cases. The manipulation of mitochondria or mitochondria-relevant pathways appears to be a promising therapeutic approach to treat the diseases.
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