Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 124, Issue -, Pages 388-394Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2018.06.038
Keywords
Alzheimer disease; Mild-cognitive impairment; Plasma; Biomarker; Lipid peroxidation; Mass spectrometry; Diagnostic model
Funding
- Instituto de Salud Carlos III (Miguel Servet I Project) [CP16/00082]
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Introduction: Alzheimer Disease (AD) standard diagnosis is based on evaluations and biomarkers that are nonspecific, expensive, or requires invasive sampling. Therefore, an early, and non-invasive diagnosis is required. As regards molecular mechanisms, recent research has shown that lipid peroxidation plays an important role. Methods: Well-defined participants groups were recruited. Lipid peroxidation compounds were determined in plasma using a validated analytical method. Statistical studies consisted of an elastic-net-penalized logistic regression adjustment. Results: The regression model fitted to the data included six variables (lipid peroxidation biomarkers) as potential predictors of early AD. This model achieved an apparent area under the receiver operating characteristics (AUC-ROCS) of 0.883 and a bootstrap-validated AUC-ROC of 0.817. Calibration of the model showed very low deviations from real probabilities. Conclusion: A satisfactory early diagnostic model has been obtained from plasma levels of 6 lipid peroxidation compounds, indicating the individual probability of suffering from early AD.
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