Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 121, Issue -, Pages 105-116Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2018.04.580
Keywords
Intimal hyperplasia; Dipeptidyl peptidase IV inhibitor; Oxidant species; Superoxide dismutase; Cell migration
Funding
- National Natural Science Foundation of China [81500209]
- University Nursing Program for Yong Scholars with Creative Talents in Heilongjiang Province [2016050]
- Heilongjiang Postdoctoral Financial Assistance [LBH-Z14215]
- Heilongjiang Provincial Department of Health [2017-114]
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Intimal hyperplasia is one of the major complications after stenting, but the underlying mechanisms remain unclear. Our previous study found that the dipeptidyl peptidase IV (DPP-4) inhibitor, Anagliptin, suppresses intimal hyperplasia after balloon injury. Here, we further investigated the effects of Anagliptin on endothelial cell (EC) migration after balloon injury. The results showed that Anagliptin administration significantly reduced intimal hyperplasia by stimulating the migration of endothelial cells, but had no effect on the medial area after balloon injury. Anagliptin elevated the total plasma activity of SOD by up-regulating the level of SOD-1, but not SOD-2, after balloon injury. Meanwhile, pre-incubation with Anagliptin suppressed the hydrogen peroxide-mediated formation of oxidant species and apoptosis in HUVECs. In vitro pre-incubation with Anagliptin promoted the migration of HUVECs via the SOD-1/RhoA/JNK signaling pathway mediating the formation of Factin. Collectively, the DPP-4 inhibitor, Anagliptin, regulates SOD-1/RhoA/JNK-mediated HUVECs migration. The results suggest that Anagliptin could serve as a potential drug to prevent intimal hyperplasia formation after balloon injury.
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