Journal
FRONTIERS IN MOLECULAR BIOSCIENCES
Volume 2, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2015.00017
Keywords
TIP48; TIP49; RUVBL1; RUVBL2; Rvb1; Rvb2; chaperone; cilium
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Funding
- Fundacao para a Ciencia e Tecnologia (Portugal) [PTDC/BBB-BEP/1724/2012, PEst-OE/EQB/LA0004/2011]
- eative Research Initiatives Program (Research Center for Chromatin Dynamics) [2009-0081563]
- Ministry of Economy and Competitiveness of the Spanish Government [SAF2011-22988, SAF2014-52301-R]
- NIH [R01 GM084465, CA166054]
- Canadian Institutes of Health Research [MOP-93778]
- Equipe Labelisee Ligue Contre le Cancer
- Institut National du Cancer grant [PLBIO10-155]
- Fundação para a Ciência e a Tecnologia [PTDC/BBB-BEP/1724/2012] Funding Source: FCT
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Pontin and Reptin are related partner proteins belonging to the AAA+ (ATPases Associated with various cellular Activities) family. They are implicated in multiple and seemingly unrelated processes encompassing the regulation of gene transcription, the remodeling of chromatin, DNA damage sensing and repair, and the assembly of protein and ribonucleoprotein complexes, among others. The 2nd International Workshop on Pontin and Reptin took place at the Instituto de Tecnologia Quimica e Biologica Antonio Xavier in Oeiras, Portugal on October 10-12, 2014, and reported significant new advances on the mechanisms of action of these two AAA+ ATPases. The major points under discussion were related to the mechanisms through which these proteins regulate gene transcription, their roles as co-chaperones, and their involvement in pathophysiology, especially in cancer and ciliary biology and disease. Finally, they may become anticancer drug targets since small chemical inhibitors were shown to produce anti-tumor effects in animal models.
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