Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 127, Issue -, Pages 198-205Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2018.03.036
Keywords
selenium; selenoproteins; selenocysteine; sex; sexual dimorphism
Funding
- US National Institutes of Health (NIH) [R01DK47320, G12MD007601]
- US NIH [U54MD007601, 5544]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK047320] Funding Source: NIH RePORTER
- National Institute on Minority Health and Health Disparities [G12MD007601, U54MD007601] Funding Source: NIH RePORTER
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Sexual dimorphism, the condition in which males and females in a species differ beyond the morphology of sex organs, delineates critical aspects of the biology of higher eukaryotes, including selenium metabolism. While sex differences in selenium biology have been described by several laboratories, delineation of the effects of sex in selenium function and regulation of selenoprotein expression is still in its infancy. This review encompasses the available information on sex-dependent parameters of selenium metabolism, as well as the effects of selenium on sex hormones. Gaps in the current knowledge of selenium and sex are identified and discussed.
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