Journal
FUTURE MICROBIOLOGY
Volume 10, Issue 12, Pages 1997-2015Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb.15.109
Keywords
biofilm; in vitro model; in vivo model; polymicrobial; synergy; antagonism
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Funding
- National Institute of Allergy and Infectious Diseases [AI105763]
- US Army Research Office [62507-LS]
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Interactions between microbes are complex and play an important role in the pathogenesis of infections. These interactions can range from fierce competition for nutrients and niches to highly evolved cooperative mechanisms between different species that support their mutual growth. An increasing appreciation for these interactions, and desire to uncover the mechanisms that govern them, has resulted in a shift from monomicrobial to polymicrobial biofilm studies in different disease models. Here we provide an overview of biofilm models used to study select polymicrobial infections and highlight the impact that the interactions between microbes within these biofilms have on disease progression. Notable recent advances in the development of polymicrobial biofilm-associated infection models and challenges facing the study of polymicrobial biofilms are addressed.
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