Journal
FUTURE MICROBIOLOGY
Volume 10, Issue 8, Pages 1307-1323Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.15.59
Keywords
Newcastle disease virus; protective immune response; reverse genetics technology; vaccine development; virus-vectored vaccine
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Funding
- Scientific Research Cooperation with America and Oceania Region, Ministry of Education [JWSM-2014-2029]
- Guizhou Province-School Cooperation Project [QKH-LHZ-2014-7669]
- Scientific Research Project of Guizhou University Talents Fund [GDRJHZ-2014-10]
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Recent advances in recombinant genetic engineering techniques have brought forward a leap in designing new vaccines in modern medicine. One attractive strategy is the application of reverse genetics technology to make recombinant Newcastle disease virus (rNDV) deliver protective antigens of pathogens. In recent years, numerous studies have demonstrated that rNDV-vectored vaccines can induce quicker and better humoral and mucosal immune responses than conventional vaccines and are protective against pathogen challenges. With deeper understanding of NDV molecular biology, it is feasible to develop gene-modified rNDV vaccines accompanied by good safety, high efficacy, low toxicity and better immunogenicity. This review summarizes the development of reverse genetics technology in using NDV as a promising vaccine vector to design new vaccines for human and animal use.
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