Journal
FUTURE MICROBIOLOGY
Volume 10, Issue 6, Pages 989-1008Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.15.37
Keywords
disease susceptibility; genetic variation; infectious disease; pattern recognition; polymorphism; receptors; single nucleotide
Categories
Funding
- Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa by foundation Limburg Sterk Merk
- province of Limburg
- Flemish government
- Hasselt University
- Ziekenhuis Oost-Limburg
- Jessa Hospital
- ERC [310372]
Ask authors/readers for more resources
Cells of the innate immune system are equipped with surface and cytoplasmic receptors for microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns and as such are crucial for the activation of the immune system. Currently, five different classes of PRRs have been described: Toll-like receptors, C-type lectin receptors, nucleotide-binding oligomerization domain-like receptors, retinoic acid-inducible gene I-like receptors and absent in melanoma 2-like receptors. Following their discovery, many sequence variants in PRR genes have been uncovered and shown to be implicated in human infectious diseases. In this review, we will discuss the effect of genetic variation in PRRs and their signaling pathways on susceptibility to infectious diseases in humans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available