Journal
FUTURE MICROBIOLOGY
Volume 10, Issue 4, Pages 517-526Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.14.140
Keywords
cardiovascular diseases; chronic renal failure; gut microbiota; inflammation; oxidative stress
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Comite Francais d'Evaluation de la Cooperation Universitaire avec le Bresil (COFECUB)
- National Council of Scientific and Technological Development (CNPq)
- Foundation for Research of the State of Rio de Janeiro (FAPERJ)
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Aim: To evaluate the gut microbial profile in chronic kidney disease (CKD) patients and evaluate the possible relationship with inflammation and cardiovascular risk. Patients & methods: Markers inflammation plasma and bacterial community profile (denaturing gradient gel electrophoresis) were analyzed. Results: The average number of bands was not different in healthy individuals and CKD patients. The number of bands was negatively associated with plasma levels of VCAM-1 in patients. Flavobacteriaceae bacterium and Listeria monocytogenes were found in patients and Lachnospiraceae bacterium and Butyrivibrio crossotus in healthy individuals. Conclusion: Although CKD patients did not present altered gut microbial profile, the sequencing of bands suggested a different microbiota between groups. The result suggests a possible relationship between gut microbiota and cardiovascular risk in CKD patients.
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