Journal
BIODEMOGRAPHY AND SOCIAL BIOLOGY
Volume 61, Issue 1, Pages 111-120Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/19485565.2014.1001886
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Funding
- National Institute on Aging (NIA) [1R21 AG034443]
- NIA [1R01 AG026676, P30 AG017265]
- National Institute for Child Health and Human Development (NICHD) [1R01 HD050764]
- World Bank
- Indonesia Office
- Australian Aid Agency (AUSAID)
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Measurement of C-reactive protein (CRP), a marker of inflammation, in dried blood spots has been increasingly incorporated into community-based social surveys internationally. Although the dried blood spot-based CRP assay protocol has been validated in the United States, it remains unclear whether laboratories in other less-developed countries can generate CRP results of similar quality. We therefore conducted external quality monitoring for dried blood spot-based CRP measurement for the Indonesia Family Life Survey and the Longitudinal Aging Study in India. Our results show that dried blood spot-based CRP results in these two countries have excellent and consistent correlations with serum-based values and dried blood spot-based results from the reference laboratory in the United States. Even though the results from duplicate samples may have fluctuations in absolute values over time, the relative order of C-reactive protein levels remains similar, and the estimates are reasonably precise for population-based studies that investigate the association between socioeconomic factors and health.
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