Journal
FOOD SCIENCE AND BIOTECHNOLOGY
Volume 27, Issue 6, Pages 1761-1769Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
DOI: 10.1007/s10068-018-0406-1
Keywords
Enzyme-assistant extraction; Celluclast; Marine algae; Sargassum polycystum; Chnoospora minima; Antioxidant
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Funding
- Ministry of Oceans and Fisheries, Korea
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Enzyme-assisted extraction is a cost-effective, safe, and efficient method to obtain bioactives from plant materials. During this study, 10 different marine algae from Sri Lanka were individually extracted by using five commercial food-grade carbohydrases. The enzymatic and water extracts of the seaweeds were analyzed for their antioxidant and anti-inflammatory activities. The highest DPPH, hydrogen peroxide (H2O2) and intracellular H2O2 scavenging abilities were observed from the Celluclast extract of Sargassum polycystum (CSp). CSp exerted protective effects against oxidative stress-induced cell death in hydrogen peroxide-induced Chang cells and in model zebrafish. The Celluclast extract of Chnoospora minima (CCm) showed the strongest anti-inflammatory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages (IC50=44.47 mu g/mL) and in model zebrafish. CCm inhibited the levels of iNOS, COX-2, PGE(2), and TNF- in LPS stimulated RAW 264.7 macrophages. Hence, CSp and CCm could be utilized in developing functional ingredients for foods, and cosmeceuticals.
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