Journal
FUTURE MEDICINAL CHEMISTRY
Volume 7, Issue 18, Pages 2485-2505Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc.15.159
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Funding
- NIMHD RCMI program [2G12MD007595]
- NIGMS [1U54GM104940]
- Louisiana Cancer Research Consortium (LCRC)
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM104940] Funding Source: NIH RePORTER
- National Institute on Minority Health and Health Disparities [G12MD007595] Funding Source: NIH RePORTER
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Background: The Wnt signaling pathway involves secreted glycoproteins that bind to the Frizzled family receptors to activate intracellular signal transduction events that regulate cell proliferation, apoptosis, cell migration and many critical aspects of developmental biology. Discussion: Aberrant Wnt signaling underlies a wide range of pathologies in humans including tumor initiation, tumor growth, cell senescence, cell death, differentiation and metastasis. The inhibition of Wnt signaling offers a novel approach for anticancer therapeutics. Conclusion: Focusing on recent developments, we reviewed the small-molecule inhibitors targeting various components of Wnt signaling pathways and the progress from the discovery of lead compounds to highly potent inhibitors with significant therapeutic potential.
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