Journal
FOOD CHEMISTRY
Volume 245, Issue -, Pages 205-222Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.10.087
Keywords
Food derived bioactive peptides; Mechanisms of action; Immunomodulatory peptides; Anticancer peptides; Food protein hydrolysates
Funding
- Egg Farmers of Canada (EFC)
- Alberta Livestock and Meat Agency Ltd. (ALMA)
- Natural Sciences and Engineering Research Council (NSERC) of Canada
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Bioactive peptides are oligopeptides that consist of 2-20 amino acids that can exert beneficial effects on human health in addition to basic nutritional effects. Food derived protein hydrolysates or peptides with immunomodulatory and anticancer activities have been reported from a variety of food protein sources such as milk, egg, fish, rice, soybean, pea, chlorella, spirulina, oyster and mussel. In vitro hydrolysis of food proteins using commercial proteolytic enzymes is the most commonly employed process for the production of immunomodulatory and anticancer food protein hydrolysates. The immunomodulatory and anticancer activities of food derived protein hydrolysates or peptides are related to the amino acid composition, sequence and length. Most immunomodulatory and anticancer food protein hydrolysates or peptides were tested using cell culture and animal models, while a few involved clinical trials. This review provides a comprehensive overview of immunomodulatory and anticancer food derived protein hydrolysates or peptides, their production and mechanisms of action.
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