Journal
FOOD CHEMISTRY
Volume 268, Issue -, Pages 347-354Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.06.048
Keywords
Berberis microphylla; Bioavailability; Calafate; GC-MS; Pharmacokinetics; Phenolic acid; Plasma
Funding
- CONICYT, Chile [FONDECYT-1140439, PFB-27]
- MECESUP, Chile [UCO 1201]
Ask authors/readers for more resources
Calafate is a berry with high concentration of anthocyanins and hydroxycinnamic acids that grows in South Patagonia. To date, no metabolism studies of phenolic compounds using calafate have been carried out. A calafate extract was characterized by HPLC-DAD-ESI-MS/MS. After extract administration (300 mg/kg), a pharmacokinetic study of phenolic compounds in gerbil plasma was performed by GC-MS/MS. Sixteen phenolic acids increased after intake. Phenylacetic acid derivatives exhibit the highest concentration, while main increase of phenolic catabolites was observed 2 h post-intake. 3-hydroxyphenylacetic and phenylacetic acids increased at 4-8h post-intake. All catabolites found in gerbil plasma exhibit concentration peaks between 0.1 and 1 mu M, however no parental anthocyanins were detected. Establish in vivo plasmatic concentration ranges of phenolic compounds derived from polyphenol consumption following WHO recommendations, plays a key role to carry out future in vitro assays in order to correctly assign biological benefits of calafate berry consumption.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available