Journal
FOOD CHEMISTRY
Volume 257, Issue -, Pages 1-6Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.02.077
Keywords
Patulin; Liquid-liquid-liquid microextraction; Liquid chromatography-mass spectrometry; Isotope dilution assay
Funding
- National Key R&D Program of China [2016YFE0206500, 2016YFF0201106]
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Quick and simple analytical methodology has been developed for the measurement of patulin in apple juice by combining single-drop liquid-liquid-liquid microextraction with isotope dilution ultra-high performance liquid chromatography-mass spectrometry. After systematic parameters optimization, the whole sample pretreatment only consisted of single extraction that consumed 1.5 mL ethyl acetate. While, other methods usually needed complicated pretreatment, including extraction, purification, evaporation and redissolution. This sample pretreatment method could greatly lower the interferences from sugar-rich matrix, and the limit of detection was 0.5 mu g/L and limit of quantification was 2 mu g/L in apple juice. Moreover, linear range covered three orders of magnitude from 2 to 2000 mu g/L. The proposed method is promising for patulin extraction and detection in apple juice, which will opens a new perspective in the enrichment of trace contaminations in high sugar complex matrix.
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