Journal
FOOD CHEMISTRY
Volume 267, Issue -, Pages 163-169Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.06.084
Keywords
Brazzein; Sweet tasting protein; Antioxidant activity; Anti-allergic effect; Anti-inflammatory activity; Functional sweetener
Funding
- National Research Foundation of Korea Grant - Korean Government [NRF-2015R1A2A1A15053693]
- Chung-Ang University Graduate Research Scholarship
Ask authors/readers for more resources
Sweet-tasting proteins may be useful as low-calorie sugar substitutes in foods, beverages, and medicines. Brazzein is an attractive sweetener because of its high sweetness, sugar-like taste, and good stability at high temperature and wide pH ranges. To investigate the bioactivities of brazzein, the antibacterial, antifungal, antioxidant, anti-inflammatory, and anti-allergic activities were determined in vitro. Brazzein showed no antibacterial and antifungal activities, although it showed approximately 45% or greater similarity to defensin, which has antimicrobial effects, and drosomycin, which is used as an antifungal agent. However, brazzein exhibited strong antioxidant effects, showing ABTS radical scavenging activity (IC50 = 12.55 mu M) and DPPH activity (IC50 > 30 mu M). Brazzein also showed anti-inflammatory activity and anti-allergic activity in a beta-hexosaminidase assay (IC50 > 15 mu M) and cyclooxygenase-2 inhibition assay (IC50 = 12.62 mu M), respectively. These results suggest that brazzein has antioxidant, anti-inflammatory, and anti-allergic activities and considerable potential as a functional sweetener. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available