Journal
FOOD CHEMISTRY
Volume 262, Issue -, Pages 110-117Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.04.090
Keywords
UHPLC/ESI Q-Orbitrap; Macrolides; Metabolites; Untargeted screening
Funding
- Scientific Research Program - Shaanxi Provincial Education Department, China [17JK0112]
- Beijing Natural Science Foundation, China [S150008]
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An analytical method for the non-target screening of macrolides and metabolites in bass (Lateolabrax) was developed using an automated on-line extraction procedure followed by ultrahigh-performance liquid chromatography coupled to electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC Q-Orbitrap). The estimated performance characteristics were satisfied, complying with the requirements of the guidelines specified in European Commission Decision 2002/657/EC. The decision limit ranged from 0.12 mu g kg(-1) to 3.61 mu g kg(-1), and detection capability ranged between 0.20 mu g kg(-1) and 6.02 mu g kg(-1). Precision in terms of relative standard deviation (RSD) was under 14% for all compounds, and the extraction recoveries ranged from 81% to 107%. Finally, the method was applied to ten different commercially important bass species and confirmed the presence of ten macrolides and metabolites. Five non-target compounds of robenidine, lincomycin hydrochloride, thiacloprid, fenbendazole, and thiabendazole were elucidated in the untargeted screening.
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