Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 120, Issue -, Pages 230-242Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2018.07.018
Keywords
Cisplatin; Nephrotoxicity; Oxidative stress; Food-derived antioxidants
Categories
Funding
- CONACYT [220046]
- PAPIIT [IN201316]
Ask authors/readers for more resources
Cancer is a relevant public health problem that represents the second leading cause of global death. In this regard, cisplatin is a highly effective antineoplastic drug used in treatment of several types of cancer, such as head and neck, testicular, ovarian, gastric, lung and breast cancer. Nevertheless, treatment with this compound leads to nephrotoxicity, which limits its use. Oxidative stress plays a pivotal role in cisplatin-induced renal damage and several dietary antioxidants have been reported to ameliorate this secondary effect. Relevant findings on the protective effects of these antioxidant agents in cisplatin-induced nephrotoxicity are summarized in this paper. Further, limitations of animal models used in these studies are discussed. Additionally, clinical studies on the protective effect of these antioxidants, as well as future directions for these kind of trials are also considered.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available