Journal
WORLD JOURNAL OF HEPATOLOGY
Volume 7, Issue 8, Pages 1020-1029Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4254/wjh.v7.i8.1020
Keywords
Hepatocellular carcinoma; Hepatitis C virus; Liver transplantation; Tumor ablation; Sorafenib
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Hepatocellular carcinoma (HCC) is the sixth most prevalent malignancy worldwide and is a rising cause of cancer related mortality. Risk factors for HCC are well documented and effective surveillance and early diagnosis allow for curative therapies. The majority of HCC appears to be caused by cirrhosis from chronic hepatitis B and hepatitis C virus. Preventive strategies include vaccination programs and anti-viral treatments. Surveillance with ultrasonography detects early stage disease and improves survival rates. Many treatment options exist for individuals with HCC and are determined by stage of presentation. Liver transplantation is offered to patients who are within the Milan criteria and are not candidates for hepatic resection. In patients with advanced stage disease, sorafenib shows some survival benefit.
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