Journal
FITOTERAPIA
Volume 124, Issue -, Pages 152-159Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.11.004
Keywords
Hedyotis diffusa; Cytotoxicity; Iridoid glycosides; Cerebrosides; Ceramides
Categories
Funding
- Program of Natural Science Foundation of Heilongjiang [H2015040]
- Postgraduate Tutor Foundation of Harbin Medical University Daqing [DSJJ2017001]
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Seven new compounds were isolated from the aerial part of Hedyotis diffusa, including three iridoid glycosides, hedyoiridoidside A - C (1-3), two cerebrosides, hedyocerenoside F (4) and G (5), and two new ceramides, hedyoceramide A (6) and B (7). And six known iridoid glycosides (8-13) were also obtained. Their structures were established by their physico-chemical constants and spectroscopic analysis. The cytotoxicity of all compounds against tumor cell lines of human cervical cancer HeLa, human leukemia HL-60, human lung cancer A459, human hepatoma HepG2, human gastric gland carcinoma BCG-823, human nasopharyngeal cancer CNE-2, human colon cancer HCT15, and human prostate cancer PC-3 were also evaluated in vitro. As a result, new compound 1 exhibited evident cytotoxicity to all tumor cell lines, and the IC50 values are from 9.5 mu M to 28.2 mu M, while new compound 2 exhibited evident cytotoxicity to Hela, HL-60, A459, HepG2, BGC-823, CNE-2, and HCT15, and the IC50 values are from 15.8 mu M to 26.2 mu M. Known compound 11 also exhibited evident cytotoxicity to HL-60, A459, HepG2, BGC-823, CNE-2, and HCT15, and the IC50 values are from 16.5 mu M to 40.4 mu M. New compounds 4-7 and known compounds 12 and 13 showed moderate cytotoxicity to some tumor cell lines.
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