Journal
FITOTERAPIA
Volume 127, Issue -, Pages 62-68Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2018.01.011
Keywords
Melia toosendan; Triterpenoids; Circular Dichroism; Anti-inflammatory; Cytotoxicity
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Funding
- National Natural Science Foundation of China [81573550, 31470416]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R63]
- Outstanding Youth Fund of the Basic Research Program of Jiangsu Province [BK20160077]
- Ph.D. Programs Foundation of Ministry of Education of China [20120096130002]
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Nine new euphane- and apotirucallane-type triterpenoids (Toosendines A-I; 1-9), along with three known tirucallane-type compounds were isolated from the barks of Melia toosendan. Their structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and circular dichroism spectra. Results of bioactivities screening exhibited that compounds 1, 4 and 5 showed remarkable NO inhibitory activities in LPS-activated RAW 264.7 macrophages, meanwhile, compounds 1 and 4 showed moderate cytotoxicities against U2OS human cancer cell line.
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