Journal
FITOTERAPIA
Volume 127, Issue -, Pages 349-355Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.03.015
Keywords
Carpesium abrotanoides L.; Sesquiterpene lactones; Structural elucidation; Cytotoxic activities
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Funding
- National Natural Science Foundations of China [81773952, 21272136, 21272137]
- Natural Science Foundation of Shennongjia Forestry District [SNJKJ2016029]
- Opening Foundation of the State Key Laboratory of Mycology [SKLMKF201501]
- Startup Foundation of China Three Gorges University
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Five new guaiane-type sesquiterpene lactones, caroguaianolide A-E (1-5), along with nine known sesquiterpene lactones (6-14) were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic date, HRESIMS analysis, and comparison of experimental and calculated ECD data. All isolated compounds (1-14) were tested in vitro for their cytotoxic activities against the MDA-MB-231, HGC-27 cancer cell lines, of which compounds 1-3, 6, 7, 11 and 12 showed significant cytotoxic activities with IC50 values ranging from 2.67 to 12.34 mu M.
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