Journal
FITOTERAPIA
Volume 127, Issue -, Pages 293-300Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.03.004
Keywords
Nerium oleander; Cardenolides; Cytotoxicity
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Funding
- Tianjin Science and Technology Research Programs of Application Foundation and Advanced Technology [14JCYBJC29000]
- Tianjin Technology Innovation System and Platform Development Plan [15PTCYSY00030]
- National Natural Science Foundation of China [81503215]
- Science Foundation of Shenzhen [JCYJ20150525092941057]
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Six new cardenolides (1-6), including three 14-hydroxylated cardenolides and three 14-carbonylated cardenolides were isolated from the dried aerial parts of Nerium oleander Linn in addition to twenty-seven known compounds (7-33). Their structures were elucidated on the basis of extensive spectroscopic evidences and single-crystal X-ray diffraction analysis. Compounds 1, 4, 7-10 and 13 exhibited significant cytotoxicity against four colon cancer cell lines (HCT116, HT29, SW620, RKO), one gastric cancer cell line (GT) and one cervical cancer cell line (HeLa) in vitro.
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