Journal
FITOTERAPIA
Volume 125, Issue -, Pages 117-122Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.01.002
Keywords
Vladimiria souliei; Sesquiterpene lactone dimers; Vlasouliolides E-I; Anti-inflammation
Categories
Funding
- Professor of Chang Jiang Scholars Program
- National Nature Science Foundation of China [81102335, 81230090, 81473109, 81520108030]
- National High-Tech Research and Development Program of China (863 Program) [2014AA022201-03]
- Shanghai Leading Academic Discipline Project [B906]
- Key laboratory of drug research for special environments
- PLA
- Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]
- Scientific Foundation of Shanghai China [12401900801, 13401900101]
- National Major Project of China [2014ZX09101003-001]
- National Key Technology R&D Program of China [2012BAI29B06]
- China Postdoctoral Science Foundation [2015M572740]
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Five rare sesquiterpene lactone dimers, vlasouliolides E-I, were isolated from Vladimiria souliei. Their chemical structures were elucidated by spectroscopic analysis. Furthermore, 2 and 4 were unambiguously confirmed by Cu-K alpha X-ray crystallographic analysis. Compounds 1, 2, 4 and 5 exhibited significant anti-inflammatory activity against LPS-induced NO production in RAW 264.7 cells with IC50 values of 1.88, 4.89, 7.24 and 2.46 mu M, respectively. Additionally, compounds 1 and 2 were revealed with potent inhibitory activity of the phosphorylation progress of NF-kappa B P65.
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