Journal
FITOTERAPIA
Volume 125, Issue -, Pages 72-77Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2017.12.023
Keywords
Meliaceae; Trichilia connaroides; 1,2-seco phragmalin-type limonoid; TDDFT/ECD calculation
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Funding
- National Natural Science Foundation of China [31470416]
- program for New Century Excellent Talents in University [NCET-2013-1035]
- Outstanding Youth Fund of the Basic Research Program of Jiangsu Province [BK20160077]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R63]
- Ph.D. Programs Foundation of Ministry of Education of China [20120096130002]
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Phytochemical investigation of the fruits from Trichilia connaroides led to the isolation of four rare 1,2-seco phragmalin-type limonoids (1-4) with C-7/28 delta-lactone ring along with two known triterpenoids (5-6). An oxygen bridge between C-1 and C-2 formed an rare 9-oxa-tricyclo[3.3.2.1(7,10)]undecane-2-ene moiety in structure of 1 and 2, and 3-4 possessed a bicyclo[5.2.1(4,10)]decane skeleton. Their structures were established based on extensive spectroscopic methods and their absolute configurations of 1 were confirmed by TDDFT/ECD calculation and comparative analysis. Compounds 5-6 showed moderate inhibitory effects on Hela tumor cell lines with inhibition ratio values of 83.8% and 87.1% at concentration 40 mu M, respectively.
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