Journal
FITOTERAPIA
Volume 125, Issue -, Pages 155-160Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.01.008
Keywords
Peganum harmala; Indole alkaloid; Cytotoxicity; Natural products
Categories
Funding
- National Natural Science Foundation of China [81773604]
- Basic Research Subject of Key Laboratory - Educational Commission of Liaoning Province of China [LZ2014044]
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Five pairs of new 2-oxoindole alkaloids, (+/-)-peganumalines A-E (1-5), and a new indole alkaloid, peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calculations. Notably, (+/-)-peganumalines A (1) represent a pair of rare 2-oxoindole dimeric alkaloid enantiomer with the hitherto unknown carbon skeleton. All isolates were tested for antiproliferative and antibacterial activities.
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