Journal
FEBS LETTERS
Volume 592, Issue 17, Pages 2874-2883Publisher
WILEY
DOI: 10.1002/1873-3468.13085
Keywords
ceRNA; long noncoding RNAs microRNA; piRNA; post-transcriptional regulation; TDMD
Funding
- Israeli Centers for Research Excellence [1796/12]
- Israel Science Foundation [1242/14, 1984/14]
- European Research Council (ERC) project lincSAFARI
- Lapon Raymond
- US-Israel Binational Science Foundation [2015171]
- BIRAX Regenerative Medicine Initiative [118047]
- Abramson Family Center for Young Scientists
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It is now evident that noncoding RNAs play key roles in regulatory networks determining cell fate and behavior, in a myriad of different conditions, and across all species. Among these noncoding RNAs are short RNAs, such as MicroRNAs, snoRNAs, and Piwi-interacting RNAs, and the functions of those are relatively well understood. Other noncoding RNAs are longer, and their modes of action and functions are also increasingly explored and deciphered. Short RNAs and long noncoding RNAs (lncRNAs) interact with each other with reciprocal consequences for their fates and functions. LncRNAs serve as precursors for many types of small RNAs and, therefore, the pathways for small RNA biogenesis can impinge upon the fate of lncRNAs. In addition, lncRNA expression can be repressed by small RNAs, and lncRNAs can affect small RNA activity and abundance through competition for binding or by triggering small RNA degradation. Here, I review the known types of interactions between small and long RNAs, discuss their outcomes, and bring representative examples from studies in mammals.
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