Journal
FEBS LETTERS
Volume 592, Issue 22, Pages 3658-3669Publisher
WILEY
DOI: 10.1002/1873-3468.13173
Keywords
actin dynamics; bacterial invasion; host-pathogen interaction; viral entry; virulence factors
Funding
- HGF
- DFG
- Helmholtz Institute for RNA-based Infection Research (HIRI)
- Bavarian Ministry of Economic Affairs and Media, Energy and Technology [0703/68674/5/2017, 0703/89374/3/2017]
- ERC
- Infect-ERA
- Cluster of Excellence 'Cells-in-Motion'
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The actin cytoskeleton and Rho GTPase signaling to actin assembly are prime targets of bacterial and viral pathogens, simply because actin is involved in all motile and membrane remodeling processes, such as phagocytosis, macropinocytosis, endocytosis, exocytosis, vesicular trafficking and membrane fusion events, motility, and last but not least, autophagy. This article aims at providing an overview of the most prominent pathogen-induced or -hijacked actin structures, and an outlook on how future research might uncover additional, equally sophisticated interactions.
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