Journal
FEBS LETTERS
Volume 592, Issue 17, Pages 2917-2931Publisher
WILEY
DOI: 10.1002/1873-3468.13161
Keywords
heat shock; metabolism; post-transcriptional gene regulation; RNA-binding protein; transcription
Funding
- BBSRC [BB/N008820/1]
- Royal Society Wolfson Research Merit Award [WM170036]
- BBSRC [BB/N008820/1] Funding Source: UKRI
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The RNA-binding proteins play essential roles in the post-transcriptional regulation of gene expression. While hundreds of RNA-binding proteins can be predicted computationally, the recent introduction of proteome-wide approaches has dramatically expanded the repertoire of proteins interacting with RNA. Besides canonical RNA-binding proteins that contain characteristic RNA-binding domains, many proteins that lack such domains but have other well-characterized cellular functions were identified; including metabolic enzymes, heat shock proteins, kinases, as well as transcription factors and chromatin-associated proteins. In the context of these recently published RNA-protein interactome datasets obtained from yeast, nematodes, flies, plants and mammalian cells, we discuss examples for seemingly evolutionary conserved 'unconventional' RNA-binding proteins that act in central carbon metabolism, stress response or regulation of transcription.
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