Journal
FEBS LETTERS
Volume 592, Issue 5, Pages 679-691Publisher
WILEY
DOI: 10.1002/1873-3468.12972
Keywords
axon; cytoskeleton; dendrite; NADPH oxidase; nervous system; neuronal polarity; pathfinding; plasticity; reactive oxygen species; synapse
Funding
- BBSRC [BB/I012273/1, BB/IO1179X/1, BB/M002934/1, BB/M002322/1]
- Biotechnology and Biological Sciences Research Council [1312476, BB/M002934/1, BB/I01179X/1, BB/I012273/1, BB/M002322/1] Funding Source: researchfish
- BBSRC [BB/I01179X/1] Funding Source: UKRI
Ask authors/readers for more resources
Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS-regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available