Related references
Note: Only part of the references are listed.Review: Central nervous system involvement in mitochondrial disease
N. Z. Lax et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2017)
Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway
Aleksandra Wojtala et al.
MITOCHONDRION (2017)
Leigh syndrome: One disorder, more than 75 monogenic causes
Nicole J. Lake et al.
ANNALS OF NEUROLOGY (2016)
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
Sandra Franco-Iborra et al.
NEUROSCIENTIST (2016)
Mitochondrial DNA Mutations Increase in Early Stage Alzheimer Disease and Are Inconsistent with Oxidative Damage
Jake G. Hoekstra et al.
ANNALS OF NEUROLOGY (2016)
Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons
Anne Gruenewald et al.
ANNALS OF NEUROLOGY (2016)
Human mitochondrial DNA replication machinery and disease
Matthew J. Young et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2016)
Mitochondrial DNA homeostasis is essential for nigrostriatal integrity
Charalampos Tzoulis et al.
MITOCHONDRION (2016)
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
Christian Dolle et al.
NATURE COMMUNICATIONS (2016)
Prevalence of Nuclear and Mitochondrial DNA Mutations Related to Adult Mitochondrial Disease
Grainne S. Gorman et al.
ANNALS OF NEUROLOGY (2015)
Mitochondrial DNA mutations in neurodegeneration
Michael J. Keogh et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)
DNA damage in neurodegenerative diseases
Fabio Coppede et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2015)
Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?
Amy Reeve et al.
AGEING RESEARCH REVIEWS (2014)
The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives
Russell H. Swerdlow et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Mitochondrial permeability transition pore is a potential drug target for neurodegeneration
Valasani Koteswara Rao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation
Dirk Mossmann et al.
CELL METABOLISM (2014)
MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE
Dmitry B. Zorov et al.
PHYSIOLOGICAL REVIEWS (2014)
Leigh syndrome associated with mitochondrial complex I deficiency due to novel mutations In NDUFV1 and NDUFS2
Samantha E. Marin et al.
GENE (2013)
Multiple sclerosis and mitochondrial gene variations: A review
Sasan Andalib et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2013)
Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation
Milena Pinto et al.
NEUROBIOLOGY OF AGING (2013)
Mitochondrial DNA deletions and depletion within paraspinal muscles
G. R. Campbell et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2013)
The Role of Oxidative Stress in Nervous System Aging
Catrina Sims-Robinson et al.
PLOS ONE (2013)
Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage
Scott R. Kennedy et al.
PLOS GENETICS (2013)
Analysis of European case-control studies suggests that common inherited variation in mitochondrial DNA is not involved in susceptibility to amyotrophic lateral sclerosis
Catherine J. E. Ingram et al.
AMYOTROPHIC LATERAL SCLEROSIS (2012)
Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease
Michael T. Lin et al.
ANNALS OF NEUROLOGY (2012)
Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease
Juan Garrido-Maraver et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice
Kati J. Ahlqvist et al.
CELL METABOLISM (2012)
The clinical spectrum of the m.10191T>C mutation in complex I-deficient Leigh syndrome
Victoria Nesbitt et al.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (2012)
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
Nicole Exner et al.
EMBO JOURNAL (2012)
A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions
Francisca Diaz et al.
HUMAN MOLECULAR GENETICS (2012)
Epigenetics, epidemiology and mitochondrial DNA diseases
Patrick F. Chinnery et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2012)
The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice
Jerome Lapointe et al.
JOURNAL OF CELL BIOLOGY (2012)
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease
Baiyang Sheng et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Mouse mtDNA mutant model of Leber hereditary optic neuropathy
Chun Shi Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Mitochondrial DNA Deletions and Neurodegeneration in Multiple Sclerosis
Graham R. Campbell et al.
ANNALS OF NEUROLOGY (2011)
Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory
Cynthia A. Massaad et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling
Yong Pan et al.
CELL METABOLISM (2011)
Mitochondrial Complex III ROS Regulate Adipocyte Differentiation
Kathryn V. Tormos et al.
CELL METABOLISM (2011)
Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-induced Redox Signaling and Human Endothelial Cell Activation
Edith Lubos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Signal transduction by reactive oxygen species
Toren Finkel
JOURNAL OF CELL BIOLOGY (2011)
The Striatum Is Highly Susceptible to Mitochondrial Oxidative Phosphorylation Dysfunctions
Alicia M. Pickrell et al.
JOURNAL OF NEUROSCIENCE (2011)
Taking a good look at free radicals in the aging process
Siegfried Hekimi et al.
TRENDS IN CELL BIOLOGY (2011)
The mtDNA Mutation Spectrum of the Progeroid Polg Mutator Mouse Includes Abundant Control Region Multimers
Sion L. Williams et al.
CELL METABOLISM (2010)
The sites and topology of mitochondrial superoxide production
Martin D. Brand
EXPERIMENTAL GERONTOLOGY (2010)
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
Jaime N. Guzman et al.
NATURE (2010)
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
Heng Du et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans
Wen Yang et al.
PLOS BIOLOGY (2010)
Somatic Mitochondrial DNA Deletions Accumulate to High Levels in Aging Human Extraocular Muscles
Patrick Yu-Wai-Man et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)
The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons
Amy K. Reeve et al.
AGING CELL (2009)
How mitochondria produce reactive oxygen species
Michael P. Murphy
BIOCHEMICAL JOURNAL (2009)
Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice
Daniel Edgar et al.
CELL METABOLISM (2009)
Mouse models of mitochondrial DNA defects and their relevance for human disease
Henna Tyynismaa et al.
EMBO REPORTS (2009)
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling
Steffi Goffart et al.
HUMAN MOLECULAR GENETICS (2009)
Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons
Hirokazu Fukui et al.
HUMAN MOLECULAR GENETICS (2009)
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
Edward Owusu-Ansah et al.
NATURE (2009)
The 4977 bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: A useful biomarker or more?
Christoph Meissner et al.
EXPERIMENTAL GERONTOLOGY (2008)
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
Marc Vermulst et al.
NATURE GENETICS (2008)
Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells
Chien-Tsun Chen et al.
STEM CELLS (2008)
The Lewy body in Parkinson's disease:: Molecules implicated in the formation and degradation of α-synuclein aggregates
Koichi Wakabayashi et al.
NEUROPATHOLOGY (2007)
Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease
P. T. Luoma et al.
NEUROLOGY (2007)
Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease
Hirokazu Fukui et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mutation of SOD1 in ALS: a gain of a loss of function
Daniela Sau et al.
HUMAN MOLECULAR GENETICS (2007)
Novel mutations of ND genes in complex I deficiency associated with mitochondrial encephalopathy
Edoardo Malfatti et al.
BRAIN (2007)
Population prevalence of the MELAS A3243G mutation
Neil Manwaring et al.
MITOCHONDRION (2007)
Mitochondrial point mutations do not limit the natural lifespan of mice
Marc Vermulst et al.
NATURE GENETICS (2007)
Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage
Hiroko P. Indo et al.
MITOCHONDRION (2007)
A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia
Emmanuelle Sarzi et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2007)
Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers
Entela Bua et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A Bender et al.
NATURE GENETICS (2006)
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
Y Kraytsberg et al.
NATURE GENETICS (2006)
Early-onset familial Parkinsonism due to POLG mutations
G Davidzon et al.
ANNALS OF NEUROLOGY (2006)
Ageing and neuronal vulnerability
MP Mattson et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
R Dutta et al.
ANNALS OF NEUROLOGY (2006)
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
A Trifunovic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice
H Tyynismaa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
M Giorgio et al.
CELL (2005)
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
GC Kujoth et al.
SCIENCE (2005)
Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans
S Srivastava et al.
HUMAN MOLECULAR GENETICS (2005)
Leigh syndrome associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFS1 gene
MA Martín et al.
ARCHIVES OF NEUROLOGY (2005)
Mitochondria, oxidants, and aging
RS Balaban et al.
CELL (2005)
Mitochondrial metabolism of reactive oxygen species
AI Andreyev et al.
BIOCHEMISTRY-MOSCOW (2005)
Single-cell analysis of mtDNA deletion levels in sporadic amyotrophic lateral sclerosis
C Mawrin et al.
NEUROREPORT (2004)
The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants
M Mattiazzi et al.
HUMAN MOLECULAR GENETICS (2004)
Shift in the localization of sites of hydrogen peroxide production in brain mitochondria by mitochondrial stress
AV Gyulkhandanyan et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Complex III releases superoxide to both sides of the inner mitochondrial membrane
FL Muller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Gene regulation and DNA damage in the ageing human brain
T Lu et al.
NATURE (2004)
Premature ageing in mice expressing defective mitochondrial DNA polymerase
A Trifunovic et al.
NATURE (2004)
A compositional segmentation of the human mitochondrial genome is related to heterogeneities in the guanine mutation rate
DC Samuels et al.
NUCLEIC ACIDS RESEARCH (2003)
Low mutant load of mitochondrial DNA G13513A mutation can cause Leigh's disease
DM Kirby et al.
ANNALS OF NEUROLOGY (2003)
Production of reactive oxygen species by mitochondria - Central role of complex III
Q Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mitochondrial threshold effects
R Rossignol et al.
BIOCHEMICAL JOURNAL (2003)
Effect of mutant α-synuclein on dopamine homeostasis in a new human mesencephalic cell line
J Lotharius et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Impaired dopamine storage resulting from α-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
J Lotharius et al.
HUMAN MOLECULAR GENETICS (2002)
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
MT Lin et al.
HUMAN MOLECULAR GENETICS (2002)
Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease
S Srivastava et al.
HUMAN MOLECULAR GENETICS (2001)
Neuropathological features of mitochondrial disorders
K Tanji et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2001)
Correlation of functional and ultrastructural abnormalities of mitochondria in mouse heart carrying a pathogenic mutant mtDNA with a 4696-bp deletion
K Nakada et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA
K Nakada et al.
NATURE MEDICINE (2001)
Progressive mitochondrial disease resulting from a novel missense mutation in the mitochondrial DNA ND3 gene
RW Taylor et al.
ANNALS OF NEUROLOGY (2001)
Reactive oxygen species and signal transduction
T Finkel
IUBMB LIFE (2001)
Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene
LGJ Nijtmans et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes
K Inoue et al.
NATURE GENETICS (2000)
Mitochondrial DNA deletion mutation levels are elevated in ALS brains
GK Dhaliwal et al.
NEUROREPORT (2000)
Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications
M Makino et al.
JOURNAL OF HUMAN GENETICS (2000)
Share Paper
