Journal
FEBS LETTERS
Volume 592, Issue 17, Pages 2845-2859Publisher
WILEY
DOI: 10.1002/1873-3468.13107
Keywords
cotranscriptional regulation; m(6)A; RNA modifications
Funding
- Novartis Research Foundation
- Swiss National Science Foundation NCCR RNA Disease [141735]
Ask authors/readers for more resources
Multiple lines of evidence suggest the RNA modification N-6-methyladonsine (m(6)A), which is installed in the nucleus cotranscriptionally and, thereafter, serves as a reversible chemical imprint that influences several steps of mRNA metabolism. This includes but is not limited to RNA folding, splicing, stability, transport and translation. In this Review we focus on the current view of the nuclear installation of m(6)A as well as the molecular players involved, the so called m(6)A writers. We also explore the effector proteins, or m(6)A readers, that decode the imprint in different cellular contexts and compartments, and ultimately, the way the modification influences the lifecycle of an RNA molecule. The wide evolutionary conservation of m(6)A and its critical role in physiology and disease warrants further studies into this burgeoning and exciting field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available