Journal
FEBS LETTERS
Volume 592, Issue 10, Pages 1643-1666Publisher
WILEY
DOI: 10.1002/1873-3468.13061
Keywords
adipogenesis; Ganoderma tsugae; lipid metabolism; metabolic adaptations; proteomics; UCP1
Funding
- Ministry of Science and Technology, R.O.C., Taipei, Taiwan [MOST 104-2320-B-039-024, MOST 105-2320-B-039-049]
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Ganoderma is classified as a top grade traditional Chinese medicine for promoting human health by regulating 'vital energy'. Its potency towards metabolism and energy homeostasis, particularly, metabolic adaptations of adipocytes, needs to be re-evaluated through an evidence-based study. Here, the triterpenoid-rich Ganoderma tsugae ethanol extract (GTEE) was found to contribute towards adipogenesis accompanied with elevated intracellular lipid metabolic flux. Additionally, proteomic profiling revealed GTEE-upregulated mitochondrial remodeling and chemical energy redox modifications, which display UCP1-positive browning fat-selective features and a NADH-mediated adaptive mechanism. GTEE-treated mice with diet-induced obesity also resulted in the amelioration of white adipocyte hypertrophy and the appearance of UCP1-positive browning adipocytes. Our novel findings unravel that GTEE could promote intracellular metabolic flexibility and plasticity followed by the induction of adipocyte browning.
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