Journal
FASEB JOURNAL
Volume 32, Issue 7, Pages 3957-3967Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201701237RR
Keywords
competing endogenous RNA; NSCLC; long noncoding RNAs; SNHG1
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Funding
- National Natural Science Foundation of China [81673014, 81372347, 81602075]
- Outstanding Academic Leaders Plan of Shanghai Municipal Science and Technology Committee [16XD1403100]
- National Key Research and Development Plan [2017YFA0104600]
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Long noncoding RNAs participate in the progression and initiation of non-small cell lung cancer (NSCLC), although the mechanism remains unknown. The lncRNA identified as small nucleolar RNA host gene 1 (SNHG1) is a novel lncRNA that is increased in multiple human cancers; however, the regulatory mechanism requires further investigation. In this study, we discovered that SNHG1 was markedly up-regulated in NSCLC tissues and cells and that SNHG1 silencing decreased tumor volumes. Moreover, we explored its regulatory mechanism and found that SNHG1 directly bound to microRNA (miRNA)-145-5p, isolating miR-145-5p from its target gene MTDH. Inhibition of SNHG1 suppressed NSCLC cell viability, proliferation, migration, and invasion in vitro, but its effect was rescued by miR-145-5p inhibition. These results demonstrate that SNHG1 contributes to NSCLC progression by modulating the miR-145-5p/MTDH axis, and it could potentially be a therapeutic target as well as a diagnostic marker.Lu, Q., Shan, S., Li, Y., Zhu, D., Jin, W., Ren, T. Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDHvia sponging miR-145-5p.
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