Journal
FASEB JOURNAL
Volume 32, Issue 4, Pages 1741-1777Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201700442R
Keywords
exercise; mitochondria; glucose uptake; plasticity; diabetes
Categories
Funding
- INSERM, Centre National de la Recherche Scientifique (CNRS), Universite Paris Descartes, and Agence Nationale de la Recherche
- Association Francaise contre les Myopathies, Ligue Nationale Contre le Cancer
- Societe Francaise de Myologie
- Canadian Institutes for Health Research (CIHR) [FDN-143247]
- Danish Council for independent Research-Medical Sciences
- Lundbeck Foundation
- Novo Nordisk Foundation
- U.S. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases [DK054902, DK059637]
- Novo Nordisk Foundation [NNF14OC0009315]
- Danish Council for Independent Research [DFF - 4004-00235]
- NNF Center for Basic Metabolic Research [Treebak Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF14OC0009315] Funding Source: researchfish
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Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism (e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.
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