Related references
Note: Only part of the references are listed.Two mammalian homologs of yeast Rad23, HR23A and HR23B, as multifunctional proteins
Masayuki Yokoi et al.
GENE (2017)
Novel UBQLN2 mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70-mediated proteolysis
Elisa Teyssou et al.
NEUROBIOLOGY OF AGING (2017)
Pathology of Neurodegenerative Diseases
Brittany N. Dugger et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease
Samir R. Nath et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease
Adewale Adegbuyiro et al.
BIOCHEMISTRY (2017)
Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
Andreas C. Woerner et al.
SCIENCE (2016)
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
Roland Hjerpe et al.
CELL (2016)
Protein aggregation and neurodegenerative diseases: From theory to therapy
Vijay Kumar et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology
Hui Yang et al.
FEBS JOURNAL (2016)
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
Yong-Jie Zhang et al.
NATURE NEUROSCIENCE (2016)
Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases
Qiuyang Zheng et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases
William B. Pratt et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)
TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA
Mei-Xia Che et al.
FEBS LETTERS (2015)
Aggregation of Polyglutamine-expanded Ataxin 7 Protein Specifically Sequesters Ubiquitin-specific Protease 22 and Deteriorates Its Deubiquitinating Function in the Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex
Hui Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Huntingtin functions as a scaffold for selective macroautophagy
Yan-Ning Rui et al.
NATURE CELL BIOLOGY (2015)
Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3
Li Zeng et al.
NEUROBIOLOGY OF DISEASE (2015)
Deactivation of TBP contributes to SCA17 pathogenesis
Tun-Chieh Hsu et al.
HUMAN MOLECULAR GENETICS (2014)
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis
Hemmo Meyer et al.
JOURNAL OF CELL SCIENCE (2014)
Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition
Anan Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Potential function for the Huntingtin protein as a scaffold for selective autophagy
Joseph Ochaba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
Jessica R. Blount et al.
NATURE COMMUNICATIONS (2014)
Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology
Hui Yang et al.
SCIENTIFIC REPORTS (2014)
PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone
Sae-Hun Park et al.
CELL (2013)
Ubiquitination Regulates the Neuroprotective Function of the Deubiquitinase Ataxin-3 in Vivo
Wei-Ling Tsou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases
Kyota Fujita et al.
NATURE COMMUNICATIONS (2013)
Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease
Fumiaki Mori et al.
ACTA NEUROPATHOLOGICA (2012)
The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System
Hwan-Ching Tai et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death
Yong-Joon Choi et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2012)
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
Hemmo Meyer et al.
NATURE CELL BIOLOGY (2012)
Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA)
Ya-Jun Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Han-Xiang Deng et al.
NATURE (2011)
Ubiquitin ligase Nedd4 promotes α-synuclein degradation by the endosomal-lysosomal pathway
George K. Tofaris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7
Alexandre Janer et al.
HUMAN MOLECULAR GENETICS (2010)
Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117
Sokol V. Todi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The ubiquitin receptor Rad23: At the crossroads of nucleotide excision repair and proteasomal degradation
Nico P. Dantuma et al.
DNA REPAIR (2009)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3
A Haacke et al.
HUMAN MOLECULAR GENETICS (2006)
The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair
Steven Bergink et al.
NEUROBIOLOGY OF DISEASE (2006)
Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin
Yong-Gang Chang et al.
PROTEIN SCIENCE (2006)
Amyloid peptide attenuates the proteasome activity in neuronal cells
S Oh et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Deubiquitinating function of ataxin-3: Insights from the solution structure of the Josephin domain
Y Mao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Protein quality control: chaperones culling corrupt conformations
AJ McClellan et al.
NATURE CELL BIOLOGY (2005)
The solution structure of the Josephin domain of ataxin-3: Structural determinants for molecular recognition
G Nicastro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
SUMO modification of Huntingtin and Huntington's disease pathology
JS Steffan et al.
SCIENCE (2004)
Proteasomal inhibition by α-synuclein filaments and oligomers
E Lindersson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Protein aggregation and neurodegenerative disease
CA Ross et al.
NATURE MEDICINE (2004)
Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex
Y Okuda et al.
DNA REPAIR (2004)
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates
KM Donaldson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein
JMY Ng et al.
GENES & DEVELOPMENT (2003)
Morphogenesis of Lewy bodies: Dissimilar incorporation of alpha-synuclein, ubiquitin, and p62
E Kuusisto et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2003)
Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis
YH Chai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Biomedicine - Toxic proteins in neurodegenerative disease
JP Taylor et al.
SCIENCE (2002)
Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
PK Auluck et al.
SCIENCE (2002)
p62 is a common component of cytoplasmic inclusions in protein aggregation diseases
K Zatloukal et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
E Kuusisto et al.
NEUROREPORT (2001)
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
S Waelter et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression
ST Suhr et al.
JOURNAL OF CELL BIOLOGY (2001)
Proteasomal function is impaired in substantia nigra in Parkinson's disease
KSP McNaught et al.
NEUROSCIENCE LETTERS (2001)
Share Paper
